HAMBURG, Germany, March 3, 2026 – We are pleased to announce that Amanda Randles, a pioneer in extreme-scale biomedical simulation, will return to ISC 2026 as the Midweek Keynote speaker on June 24. The keynote continues ISC’s tradition of spotlighting visionary leaders whose work expands the boundaries of scalable computing and its real-world applications.
Randles, the Alfred Winborne Mordecai and Victoria Stover Mordecai Associate Professor at Duke University, gained widespread recognition at ISC as the recipient of the Jack Dongarra Early-Career Award in 2024. After serving as the ISC Research Paper program chair last year, she returns to demonstrate how HPC is moving medicine from reactive treatment to a new era of proactive, patient-specific care in a keynote titled “HPC for Vascular Digital Twins.”
Over the last few years, Randles’ work has become synonymous with extreme-scale biomedical simulation. In her keynote address, she will demonstrate how HPC enables the creation of patient-specific vascular digital twins. These models integrate medical imaging, physiological data, and large-scale blood flow simulations into dynamic, high-fidelity representations of the human circulatory system.
In her abstract, Randles explains that this technology could reshape healthcare by moving beyond “snapshot” analyses. Unlike static models, vascular digital twins capture the dynamic nature of physiology. This requires sustained simulation across thousands to millions of cardiac cycles, the management of massive multimodal datasets, and rapid analysis needed for clinical work.
Randles will discuss how GPU-accelerated supercomputing and extreme-scale parallelism make this kind of modeling feasible.
Her talk will further explore the convergence of:
- Wearable Sensors: Coupling continuous data streams with large-scale twins.
- Immersive Visualization: Using advanced interfaces to support early detection and risk assessment.
- Multiscale Simulation: Advancing models for diseases ranging from cardiovascular conditions to cancer.
About Amanda Randles
Amanda Randles is the Director of the Duke Center for Computational and Digital Health Innovation. Her research integrates HPC, machine learning, and biophysical simulation to advance patient-specific care. Her contributions have been recognized with numerous distinctions, including the ACM Prize in Computing, the NIH Pioneer Award, NSF Career Award and the ACM Grace Hopper Award. Prior to her academic career, she worked as a software engineer at IBM on the Blue Gene supercomputing team.
Randles received her Ph.D. in Applied Physics from Harvard University, an M.S. in Computer Science from Harvard, and a B.A. in Computer Science and Physics from Duke. Prior to graduate school, she worked as a software engineer at IBM on the Blue Gene supercomputing team.
Join ISC High Performance 2026 in #ConnectingTheDots
ISC 2026 returns to the Congress Center Hamburg from June 22 – 26 for its 41st edition. Since its inception in 1986, it has been recognized as the world’s oldest and Europe’s most attended event for the HPC community, and increasingly for AI and quantum professionals interested in performance, energy efficiency, and cost-effectiveness.
Nages Sieslack
nages.sieslack@isc-group.com
